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Paper   IPM / Cognitive Sciences / 7892
School of Cognitive Sciences
  Title:   Cross state-dependent retrieval between histamine and lithium
  Author(s): 
1.  M.R. Zarrindast
2.  S. Fazli-Tabaei
3.  A. Khalilzadeh
4.  M. Farahmanfar
5.  SH. Yahyavi
  Status:   Published
  Journal: PHYSIOL BEHAV
  No.:  1-2
  Vol.:  86
  Year:  2005
  Pages:   154-163
  Supported by:  IPM
  Abstract:
Histamine and lithium state-dependent (StD) retrieval of passive avoidance task and their interactions was examined in mice. The pre-training or pre-test intracerebroventricular (i.c.v.) injection of histamine (20 mug/mouse) impaired retrieval when it was tested 24 h later. In the animals, in which retrieval was impaired due to histamine pre-training administration, pre-test administration of histamine, with the same dose, restored retrieval. The H1 blocker, pyrilamine (20 mug/mouse, i.c.v.), but not the H(2) blocker; ranitidine prevented the restoration of retrieval by pre-test histamine. The pre-training (5 and 10 mg/kg) or pre-test (5 mg/kg) injection of lithium also impaired retrieval, when it was tested 24 h later. In the animals that received lithium (5 mg/kg) or histamine (20 mug/mouse) as pre-training treatment, administration of histamine, clobenpropit or lithium, respectively, resulted in restoration of memory retrieval. Neither pyrilamine nor ranitidine prevented the restoration of retrieval by pre-test lithium. In conclusion, histamine or lithium can induce state-dependent retrieval and a cross-StD exists between these drugs, which may be mediated through the inositol pathway.


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